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Two New Cholestanol Glycosides from the Roots and Rhizomes of Smilacina henryi

Original Article

JOURNAL 1248

Records of Natural Products
VOLUME & ISSUE
Year: 2019 Issue: 6 November-December
PAGES
p.499 - 505
DOI ADDRESS
http://doi.org/10.25135/rnp.19.03.1248
STATISTICS
Viewed 2328 times.
AUTHORS
  • Xin Zhang
  • Jing Sun
  • Shuo Zhang
  • Yafeng Yan
  • Rongxin Zhang
  • Xuanji Xue
  • Zengjun Guo
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Abstract: Two new cholestanol glycosides (1 and 2) were obtained from the roots and rhizomes of Smilacina henryi. Their structures were determined as 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione 3-O-β-D-glucopyranosyl-(1→2)-β-D-galactopyranoside (1), 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione 3-O-β-D-glucopyranosyl-(1→2)- [β-D-glucopyranosyl-(1→3)]-β-D-galactopyranoside (2), by physicochemical properties and spectroscopic methods. In addition, the isolated glycosides were tested for their cytotoxic activity against human HepG2 tumor cells and compound 2 showed moderate activity with IC50 value of 59.32 μM.

 KEYWORDS
  • Smilacina henryi
  • cholestanol glycosides
  • structure determination
  • cytotoxicity

SUPPORTING INFORMATION

Supporting Information
Download File A9-130-RNP-1904-1248.pdf (603.47 KB)