JOURNAL 1559


Records of Natural Products
VOLUME & ISSUE
Year: 2020 Issue: 5 September-October
PAGES
p.378 - 382
STATISTICS
Viewed 2375 times.
AUTHORS
  • Ming Zhao
  • Gang Chen
  • Tingting Lin
  • Yu Lu
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new labdane diterpene (1) and five known compounds (2-6) were isolated from the aerial parts of Chloranthus serratus. The gross structure of compound 1 was resolved by NMR and HRESIMS data. The absolute configuration of 1 was determined by comparing CD spectrum and specific rotations with those of the co-isolated known analogue 2. The known compounds were identified to be agathic acid (2), altechromone (3), chlorajapolide F (4), shizukanolide (5), and chloranthalactone E (6) by comparing the NMR data with those in the literature. ll compounds were evaluated for their inhibitions against NO production in LPS-activated RAW 264.7 macrophages, compounds 2 and 6 showed moderate inhibitions with IC50 values of 45.2 ± 1.2 and 35.3 ± 0.9 mM.

KEYWORDS
  • Chloranthus serratus
  • labdane diterpene
  • inhibitions
  • NO production

SUPPORTING INFORMATION


Supporting Information
Download File A9-175-RNP-2002-1559-SI.pdf (1.14 MB)