JOURNAL 1559
Records of Natural Products
VOLUME & ISSUE
Year: 2020 Issue: 5 September-October
Year: 2020 Issue: 5 September-October
PAGES
p.378 - 382
p.378 - 382
STATISTICS
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Viewed 2457 times.
GRAPHICAL ABSTRACT
ABSTRACT
A new labdane diterpene (1) and five known compounds (2-6) were isolated from the aerial parts of Chloranthus serratus. The gross structure of compound 1 was resolved by NMR and HRESIMS data. The absolute configuration of 1 was determined by comparing CD spectrum and specific rotations with those of the co-isolated known analogue 2. The known compounds were identified to be agathic acid (2), altechromone (3), chlorajapolide F (4), shizukanolide (5), and chloranthalactone E (6) by comparing the NMR data with those in the literature. ll compounds were evaluated for their inhibitions against NO production in LPS-activated RAW 264.7 macrophages, compounds 2 and 6 showed moderate inhibitions with IC50 values of 45.2 ± 1.2 and 35.3 ± 0.9 mM.
KEYWORDS- Chloranthus serratus
- labdane diterpene
- inhibitions
- NO production
