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Scoparic acid E: A New Labdane Diterpenoid on Attenuating Palmitate Induced Viability in MIN6 Cells from Scoparia dulcis

Short Report

JOURNAL 1567

Records of Natural Products
VOLUME & ISSUE
Year: 2020 Issue: 5 September-October
PAGES
p.383 - 386
DOI ADDRESS
http://doi.org/10.25135/rnp.177.20.02.1567
STATISTICS
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AUTHORS
  • Zhang Xiaopo
  • Caiyun Zhang
  • Chen Lizhen
  • Li Yiying
  • Na Wei
  • Zhang Lu
  • Dong Lin
  • Zhang Yong
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new labdane diterpenoid, named Scoparic acid E (1), was obtained from the medicinal plant of Scoparia dulcis L. The structure of Scoparic acid E (1) was elucidated and characterized through detailed physical analyses of its NMR spectroscopic data and HRMS. Scoparic acid E (1) was tested for its effect on attenuating palmitate-induced viability at 25 and 50 μM. The results showed that compound 1 significantly attenuated palmitate-induced viability in MIN6 cells.

 KEYWORDS
  • Scoparia dulcis L
  • scoparic acid E
  • labdane diterpenoid
  • palmitate-induced viability

SUPPORTING INFORMATION

Supporting Information
Download File A10-177-RNP-2002-1567-SI.pdf (1.42 MB)