JOURNAL 1726
Records of Natural Products
VOLUME & ISSUE
Year: 2021 Issue: 1 January-February
Year: 2021 Issue: 1 January-February
PAGES
p.46 - 52
p.46 - 52
STATISTICS
Viewed 2984 times.
Viewed 2984 times.
GRAPHICAL ABSTRACT
ABSTRACT
Two new ecdysteroid glycosides, sileneosides I and J (1 and 2), along with four known ecdysteroids (3–6) were isolated from the rhizomes of Silene tatarinowii Regel. Their structures were determined based on physicochemical properties and spectroscopic methods. In addition, the cytotoxicity of compounds 1–6 was evaluated in vitro in human SGC790, HCT116, A549, and BEL7404 tumor cell lines. The results showed that compounds 1 and 2 exhibited weak cytotoxicity against SGC790 (IC50 82.58 ± 0.53 μM) and A549 cells (96.62 ± 0.58 μM), respectively.
KEYWORDS- Silene tatarinowii
- ecdysteroids
- sileneosides I
- sileneosides J
- cytotoxic activity
