JOURNAL 1643
Records of Natural Products
VOLUME & ISSUE
Year: 2021 Issue: 2 March-April
Year: 2021 Issue: 2 March-April
PAGES
p.76 - 81
p.76 - 81
STATISTICS
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Viewed 2103 times.
GRAPHICAL ABSTRACT
ABSTRACT
A new alkaloid glycoside (1) and six known alkaloids (2–7) were isolated from the stems of Zanthoxylum dissitum Hemsl.. The structure of compound 1 was resolved by spectrum data, including MS, IR, UV, and MS. All compounds obtained in this research were evaluated for their inhibitions against NO release from LPS-activated RAW264.7 macrophages. Compounds 1-3, 6 and 7 showed significant inhibition activities with IC50 values of 26.12±0.81, 8.41±0.23, 13.75±0.54, 6.97±0.77, and 5.78±0.42 μM, respectively.
KEYWORDS
- Zanthoxylum dissitum Hemsl.
- alkaloid
- macrophages
- NO
