JOURNAL 1837


Records of Natural Products
VOLUME & ISSUE
Year: 2021 Issue: 4 July-August
PAGES
p.261 - 266
STATISTICS
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AUTHORS
  • Yan Liu
  • Xin Yin
  • Yanping Sun
  • Yuan Liu
  • Dongxv Lu
  • Yuanyuan Zhou
  • Mohammed Algradi Adnan
  • Juan Pan
  • Wei Guan
  • Bingyou Yang
  • Haixue Kuang
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Fifteen phenylpropanoids were isolated from the ethanol extract of the roots of Solanum melongena L., including a new compound, melongenapanoid A (1), together with fourteen known compounds (2-15). Their chemical structures were elucidated by 1D and 2D NMR and HR-MS data according to those values of the literatures. The fourteen known compounds (2-15) were all firstly isolated from this plant. While, the isolates were evaluated for the inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 cell line. Compounds 2, 4 and 5 showed moderate inhibition of NO production with IC50 values of 28.7, 24.4 and 32.6 μM, respectively.

KEYWORDS
  • Solanum melongena L
  • natural products
  • phenylpropanoids
  • anti-inflammatory activity

SUPPORTING INFORMATION


SciFinder-melongenapanoid A
Download File YX-156.molSubstance_04_24_2020_144204.pdf (187.78 KB)
Supporting Information
Download File A4-211-RNP-2010-1837-SI.pdf (1.61 MB)