A New Phenylpropanoid from the Roots of Solanum melongena L. and Evaluation of Anti-inflammatory Activity

Original Article

JOURNAL 1837

Records of Natural Products

VOLUME & ISSUE

Year: 2021 Issue: 4 July-August

PAGES

p.261 - 266

DOI ADDRESS

http://doi.org/10.25135/rnp.211.20.10.1837

STATISTICS

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AUTHORS

Yan Liu
Xin Yin
Yanping Sun
Yuan Liu
Dongxv Lu
Yuanyuan Zhou
Mohammed Algradi Adnan
Juan Pan
Wei Guan
Bingyou Yang
Haixue Kuang

GRAPHICAL ABSTRACT

ABSTRACT

Fifteen phenylpropanoids were isolated from the ethanol extract of the roots of Solanum melongena L., including a new compound, melongenapanoid A (1), together with fourteen known compounds (2-15). Their chemical structures were elucidated by 1D and 2D NMR and HR-MS data according to those values of the literatures. The fourteen known compounds (2-15) were all firstly isolated from this plant. While, the isolates were evaluated for the inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 cell line. Compounds 2, 4 and 5 showed moderate inhibition of NO production with IC50 values of 28.7, 24.4 and 32.6 μM, respectively.

KEYWORDS

Solanum melongena L
natural products
phenylpropanoids
anti-inflammatory activity

SUPPORTING INFORMATION

SciFinder-melongenapanoid A

Download File YX-156.molSubstance_04_24_2020_144204.pdf (187.78 KB)

Supporting Information

Download File A4-211-RNP-2010-1837-SI.pdf (1.61 MB)