JOURNAL 2000


Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 1 January-February
PAGES
p.27 - 33
STATISTICS
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AUTHORS
  • Dong-xiang Wu
  • Jin-hai Yu
  • Xiu-qing Song
  • Yu-zhen Ma
  • Peipei Shan
  • Hua Zhang
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Two new rearranged abietane diterpenoids (1 and 2), together with eleven previously described analogues (313), were obtained from the ethanolic extract of a traditional ethnological herb, Clerodendrum bungei. The structures with absolute configurations of the new compounds were unambiguously characterized via spectroscopic methods, and that of the formerly reported crolerodendrum B (3) was corrected in the present work. Biological assessment of these isolates revealed that diterpenoids 2, 4, 6 and 12 showed significant inhibition against a-glucosidase enzyme with IC50 values in the range of 17.0–25.7 mM.

KEYWORDS
  • Clerodendrum bungei
  • abietane diterpenoid
  • alpha-glucosidase

SUPPORTING INFORMATION


Supporting Information
Download File A2-245-RNP-2103-2000-SI.pdf (3.67 MB)