JOURNAL 2000
Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 1 January-February
Year: 2022 Issue: 1 January-February
PAGES
p.27 - 33
p.27 - 33
STATISTICS
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Viewed 1558 times.
GRAPHICAL ABSTRACT
ABSTRACT
Two new rearranged abietane diterpenoids (1 and 2), together with eleven previously described analogues (3–13), were obtained from the ethanolic extract of a traditional ethnological herb, Clerodendrum bungei. The structures with absolute configurations of the new compounds were unambiguously characterized via spectroscopic methods, and that of the formerly reported crolerodendrum B (3) was corrected in the present work. Biological assessment of these isolates revealed that diterpenoids 2, 4, 6 and 12 showed significant inhibition against a-glucosidase enzyme with IC50 values in the range of 17.0–25.7 mM.
KEYWORDS- Clerodendrum bungei
- abietane diterpenoid
- alpha-glucosidase
