JOURNAL 2014


Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 1 January-February
PAGES
p.66 - 73
STATISTICS
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AUTHORS
  • Tran Thi Minh
  • Nguyen Hoai Thu
  • Ho Khanh Toan
  • Tran Thuong Quang
  • Nguyen Thi Viet Thanh
  • Tran Thu Huong
  • Tran Van Sung
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The analysis of a methanol extract of mangrove plant Acrostichum aureum collected from Thai Binh coastal area led to isolation of three new compounds, 4-(3ʹ-O-sulfate-4ʹ-hydroxyphenyl)-2-butanone (1), 4-(3ʹ-O-sulfate-4ʹ-hydroxyphenyl)-2(R)-butanol (2), and dihydrodehydrodiconiferyl alcohol 9-O-sulfate (3) beside five known phenolic compounds (4-8). The structures of isolated compounds were determined by extensive analysis of their spectroscopic evidence (IR, 1D and 2D NMR, HR ESI-MS) as well as comparison with the data reported in the literature. The cytotoxic activity of these compounds was evaluated on SK-LU-1, HepG2, and MCF7 cell lines using SRB assay. The results showed that compound 4 exhibited weak cytotoxicity against three tested cell lines. The other compounds were considered as inactive in this test.

KEYWORDS
  • Acrostichum aureum
  • Pteridaceae
  • 4-arylbutanoid sulfate
  • neolignan sulfate
  • cytotoxicity

SUPPORTING INFORMATION


Supporting Information
Download File A6-252-RNP-2103-2014-SI.pdf (2.07 MB)