JOURNAL 2014
Records of Natural Products
Year: 2022 Issue: 1 January-February
p.66 - 73
Viewed 1967 times.
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Tran Thi Minh
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Nguyen Hoai Thu
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Ho Khanh Toan
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Tran Thuong Quang
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Nguyen Thi Viet Thanh
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Tran Thu Huong
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Tran Van Sung
GRAPHICAL ABSTRACT
ABSTRACT
The analysis of a methanol extract of mangrove plant Acrostichum aureum collected from Thai Binh coastal area led to isolation of three new compounds, 4-(3ʹ-O-sulfate-4ʹ-hydroxyphenyl)-2-butanone (1), 4-(3ʹ-O-sulfate-4ʹ-hydroxyphenyl)-2(R)-butanol (2), and dihydrodehydrodiconiferyl alcohol 9-O-sulfate (3) beside five known phenolic compounds (4-8). The structures of isolated compounds were determined by extensive analysis of their spectroscopic evidence (IR, 1D and 2D NMR, HR ESI-MS) as well as comparison with the data reported in the literature. The cytotoxic activity of these compounds was evaluated on SK-LU-1, HepG2, and MCF7 cell lines using SRB assay. The results showed that compound 4 exhibited weak cytotoxicity against three tested cell lines. The other compounds were considered as inactive in this test.
KEYWORDS- Acrostichum aureum
- Pteridaceae
- 4-arylbutanoid sulfate
- neolignan sulfate
- cytotoxicity
