JOURNAL 2048


Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 2 March-April
PAGES
p.144 - 149
STATISTICS
Viewed 1270 times.
AUTHORS
  • Xiaoxiao Chen
  • Jiangmiao Hu
  • Siyu Wu
  • Hongsu Zhao
  • Daiyin Peng
  • Deling Wu
  • Feng-Qing Xu
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Bioassay-guided led to the isolation of five compounds, including a new picrotoxane-type sesquiterpene lactone, aduncin C (1), together with four known ones (2-5) from Dendrobium huoshanense. Their structures were elucidated by means of extensive spectroscopic analysis. Biological evaluation of the isolates against four human cancer cell lines indicated broad-spectrum and cytotoxic activities with IC50 values ranging from 4.08 to 26.75 μM. Among them, α-dihydropicrotoxinin (3) exhibited significant cell proliferation inhibitory activity, especially for HL-60 (IC50 5.81 μM), MCF- 7 (IC50 6.49 μM), SW-480 (IC50 6.80 μM), respectively.

KEYWORDS
  • Dendrobium huoshanense
  • picrotoxane-type sesquiterpene
  • cytotoxicity

SUPPORTING INFORMATION


Supporting Information
Download File A4-260-RNP-2104-2048-SI.pdf (1.16 MB)