Neoflavonoids from the Heartwood of Dalbergia melanoxylon

Short Report

JOURNAL 2071

Records of Natural Products

VOLUME & ISSUE

Year: 2022 Issue: 2 March-April

PAGES

p.200 - 205

DOI ADDRESS

http://doi.org/10.25135/rnp.267.2105.2071

STATISTICS

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AUTHORS

Zhangjun Xu
Yang Liu
Xiaowei Meng
Li Yang
Feng Shao
Ronghua Liu
Lanying Chen

GRAPHICAL ABSTRACT

ABSTRACT

A new neoflavonoid, (1R,8R,9R)-pterolinuse K (1) and six known neoflavonoids (2-7) were obtained from the heartwood of Dalbergia melanoxylon. The structure of the new neoflavonoid was elucidated by extensive NMR investigation, and X-ray crystallographic analysis. Compounds 3 and 6 showed anti-inflammatory activity with IC50 values 23.14 ± 0.30 and 19.46 ± 1.02 μΜ, respectively. Compounds 2, 3, 4, 6, 7 were showed cytotoxicity on Caco-2, MDA-MB-468, MDA-MB-231, CT26 cell lines. Moreover, compounds 2, 4 exhibited the significant activity in MDA-MB-231 cell lines with IC50 values 7.54 ± 1.50 and 7.23 ± 0.40 μΜ, respectively.

KEYWORDS

Dalbergia melanoxylon
neoflavonoids
anti-inflammatory activity
anti-tumor activity

SUPPORTING INFORMATION

Supporting Information

Download File A10-267-RNP-2105-2071-SI.pdf (1.85 MB)