JOURNAL 2158
Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 4 July-August
Year: 2022 Issue: 4 July-August
PAGES
p.346 - 352
p.346 - 352
STATISTICS
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Viewed 2026 times.
AUTHORS
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Vu Thi Kim Oanh
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Huu Giap Tran
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Thu Ha Bui
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Thi Lan Phuong Diep
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Thi Van Anh Nguyen
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Le Nguyen Thanh
GRAPHICAL ABSTRACT
ABSTRACT
Phytochemical study of Adinandra hainanensis stems led to the isolation of a new triterpene lupan-3β,20-dihydroxy-28-carbaldehyde (1) and eleven known compounds 2-12. The stems of A. hainanensis was rich in lupane-type triterpenes, especially betulinic acid (9) was abundant (around 0.45% w/w). The isolated triterpenes, including new compound 1 showed strong α-glucosidase inhibitory activity with IC50 values ranging of 2.27 ± 0.05 μg/mL to 12.25 ± 0.36 μg/mL. In the cytotoxic evaluation, betulinic acid, the major component, showed good cytotoxic activity against all tested cancer cell lines while new compound 1 was weakly active.
KEYWORDS- Adinandra hainanensis
- lupane triterpene
- betulinic acid
- α-glucosidase
- cytotoxicity
