JOURNAL 2258
Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 5 September-October
Year: 2022 Issue: 5 September-October
PAGES
p.509 - 514
p.509 - 514
STATISTICS
Viewed 1779 times.
Viewed 1779 times.
AUTHORS
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Yanling Liu
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Yangang Cao
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Mengnan Zeng
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Mengna Wang
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Chen Xu
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Xiling Fan
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Chen He
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Yingjie Ren
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Xiaoke Zheng
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Weisheng Feng
GRAPHICAL ABSTRACT
ABSTRACT
A new eremophilanolide, serratifolide F (1), and six known compounds were isolated from the fresh roots of Rehmannia glutinosa. Their structures were characterized by analysis of NMR, CD, HRESIMS, and comparison of the data in previous literatures. The protective effects against lipopolysaccharide (LPS)-stimulated damage on normal rat kidney tubule epithelioid (NRK-52e) cells of the compounds were evaluated using MTT assay and real time cellular analysis (RTCA). The results showed that compound 3 exhibited renoprotective activity with EC50 value of 45.1 μM.
KEYWORDS- Scrophulariacea
- Rehmannia glutinosa
- eremophilanolide
- glycosides
- renoprotective activity
