JOURNAL 2232
Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 5 September-October
Year: 2022 Issue: 5 September-October
PAGES
p.409 - 416
p.409 - 416
STATISTICS
Viewed 2222 times.
Viewed 2222 times.
AUTHORS
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Qingmei Feng
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Hong Zhang
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Jing Wang
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Hongbin Li
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Lingxia Zhang
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Erping Xu
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Suiqing Chen
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Zhimin Wang
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Liping Dai
GRAPHICAL ABSTRACT
ABSTRACT
A new iridoid glycoside, cornusglucoside I (1), and a new natural product methyl 4-(3′,4′-dihydroxyphenyl)-4-oxobutanoate (2), together with two known isolated compounds (3-4) were obtained from the 30% ethanol extract of the wine-processed Corni fructus. Their structures were clarified by spectroscopic analysis and literature data. The absolute configuration of 1 was elucidated by ECD calculation. By evaluating the NO production induced by LPS in RAW 264.7 cells to assess the anti-inflammatory activities of isolated compounds. Among the tested compounds, compounds 3 and 4 exhibited stronger anti-inflammatory activity than the positive drug dexamethasone (6 μM), which may be potential anti-inflammatory drugs.
KEYWORDS
- Iridoid glycoside
- wine-processed Corni fructus
- anti-inflammatory activity
