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A New Alkaloid from Ormosia hosiei Hemsl. et Wils

Original Article

JOURNAL 2340

Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 6 November-December
PAGES
p.579 - 584
DOI ADDRESS
http://doi.org/10.25135/rnp.316.2201.2340
STATISTICS
Viewed 2216 times.
AUTHORS
  • Lijun Zheng
  • Linjing Zhang
  • Jianyong Huang
  • Xiaoqin Zhang
  • Mingqing Huang
  • Huiyou Xu
  • Lin Ni
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new alkaloid, hositisine E (1) and nine known compounds (2-10) were isolated from the seeds of Ormosia hosiei Hemsl. et Wils. Compound 1 was identified on the basis of a combination of UV, IR, NMR, CD and HRESIMS data. The structures of the known compounds were determined as isoprunetin (2), biochanin A (3), ononin (4), 4',8-dimethoxy-7-O-β-D-glucopyranosylisoflavone (5), sphaerobioside (6), ambocin (7), rutin (8), kaempferol-3-rutinoside (9) and narcissin (10). In the anti-inflammatory activity assay, compounds 1-3, 7 displayed inhibitory effects against lipopolysaccharide-induced interleukin-6 release in RAW264.7 macrophages, exhibiting IC50 values of 19.4 – 58.9 μM.

 KEYWORDS
  • Ormosia hosiei
  • cytisine-like alkaloid
  • hositisine
  • flavonoid
  • anti-inflammatory
  • IL-6

SUPPORTING INFORMATION

Supporting Information
Download File A6-316-RNP-22201-2340-SI.pdf (1 MB)