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A Neoprzewaquinone Analogue from Salvia miltiorrhiza Bunge

Original Article

JOURNAL 2253

Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 6 November-December
PAGES
p.572 - 578
DOI ADDRESS
http://doi.org/10.25135/rnp.313.2111.2253
STATISTICS
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AUTHORS
  • Jie Yan
  • Wenxiu Guo
  • Lanyu Zhou
  • Zhixing Cao
  • Jin Pei
  • Yun Deng
  • Bo Li
  • Ding Liu
  • Dale Guo
  • Cheng Peng
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

(3R,3′R)-2,2′,3,3′-tetrahydroneoprzewaquinone A (1), a previously undescribed neoprzewaquinone analogue, was isolated from the root of Salvia miltiorrhiza Bunge. Its absolute configuration was elucidated by comprehensive analyses of spectra including NMR and MS combined with ECD calculations. MTT assay indicated that 1 can inhibit the proliferation of MV-4-11, TMD-8, MOLM-13, and H460 cell lines with IC50 values of 2.21 μM, 2.48 μM, 3.39 μM, and 2.02 μM respectively.

 KEYWORDS
  • Salvia miltiorrhiza Bunge
  • (3R,3′R)-2,2′,3,3′-tetrahydroneoprzewaquinone A
  • cytotoxic activity

SUPPORTING INFORMATION

Supporting Information
Download File A5-313-RNP-2111-2253-SI.pdf (1.94 MB)