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A New Megastigmane Glycoside and Other Constituents from Amomum muricarpum Elmer

Short Report

JOURNAL 2395

Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 1 January-February
PAGES
p.184 - 188
DOI ADDRESS
http://doi.org/10.25135/rnp.333.2203.2395
STATISTICS
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AUTHORS
  • Tran Thi Thu Phuong
  • Nguyen Hai Dang
  • Nguyen Thi Hong Anh
  • Do Hoang Giang
  • Dat Nguyen Tien
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

An updated phytochemical investigation of the aerial parts of Amomum muricarpum Elmer led to the isolation of a new megastigmane glycoside, (3S*,5R*,6R*,9R*)-6,9-epoxy-3,5-megastigmanediol 3-O-rutinoside (1) and five known phenolic compounds. Their structures were elucidated by spectroscopic evidence including HRESIMS and NMR data. All the isolates were reported for the first time from this plant. The anti-inflammatory effect via the inhibition of NO production of isolated compounds was evaluated in LPS-stimulated RAW 264.7 cells. Our study found that 5,7-dimethoxyflavone (4) was the most active compound with the IC50 = 29.5 µM.

 KEYWORDS
  • Amomum muricarpum
  • megastigmane
  • 5,7-dimethoxyflavone
  • anti-inflammation

SUPPORTING INFORMATION

Supporting Information
Download File A14-333-RNP-2203-2395-SI.pdf (1.43 MB)