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Psammosilenin C, a New Cyclic Peptide from Psammosilene tunicoides

Short Report

JOURNAL 2399

Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 1 January-February
PAGES
p.179 - 183
DOI ADDRESS
http://doi.org/10.25135/rnp.336.2203.2399
STATISTICS
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AUTHORS
  • Xiuxia Yang
  • Xishan Bai
  • Hongrui Li
  • Jingxian Sun
  • Yong Xiong
  • Yanhong Li
  • Xiangzhong Huang
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Phytochemical investigation of Psammosilene tunicoides led to isolation of a new cyclic peptide, psammosilenin C (1) and three known compounds, 1-O-(β-D-glucopyranosyl)-(2S,3R,4E,8E)-2-[(2R)-2-hydroxypentadecanoylamino]-4,8-octadecadiene-1,3-diol (2), dihydroferulic acid (3) and vanillylacetone (4). Their structures were elucidated by comprehensive spectroscopic methods, including 1D and 2D NMR spectroscopic, and HR-ESI-MS spectrometric data. Compounds 1, 2 and 4 showed inhibitory activities on lipopolysaccharide (LPS)-induced NO release in RAW 264.7 cells.

 KEYWORDS
  • Psammosilene tunicoides
  • cyclic peptide
  • anti-inflammatory activity

SUPPORTING INFORMATION

Supporting Information
Download File A13-336-RNP-2203-2399-SI.pdf (1.83 MB)