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Three New Chromone Derivatives from the Deep-Sea-Derived Fungus Penicillium thomii

Short Report

JOURNAL 2433

Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 1 January-February
PAGES
p.174 - 178
DOI ADDRESS
http://doi.org/10.25135/rnp.330.2204.2433
STATISTICS
Viewed 2289 times.
AUTHORS
  • Fan Yang
  • Yu Liu
  • Xiaoqian Zhang
  • Wan Liu
  • Ying Qiao
  • Wei Xu
  • Qin Li
  • Zhongbin Cheng
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Chemical investigation of the EtOAc extract of a deep-sea-derived fungus Penicillium thomii Maire YPGA3 cultured on rice solid medium led to the isolation of three new chromone analogs, named penithochromones U-W (1-3), along with six known compounds (4-9). The structures were determined by extensive analyses of spectroscopic data (NMR and HRESIMS data). Compounds 1-3 are 5,7-dioxygenated chromone analogs bearing an aliphatic acid side chain. All isolated compounds were inactive toward the a-glucosidase at the concentration of 200 mM.

 KEYWORDS
  • Penicillium thomii;
  • deep-sea fungus
  • chromone derivative
  • chromone derivative
  • penithochromone

SUPPORTING INFORMATION

Supporting Information
Download File A12-330-RNP-2204-2433-SI.pdf (1.76 MB)