JOURNAL 2352
Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 1 January-February
Year: 2023 Issue: 1 January-February
PAGES
p.195 - 200
p.195 - 200
STATISTICS
Viewed 1723 times.
Viewed 1723 times.
AUTHORS
-
Nayara F. Gomes
-
Manoel Leão L. Júnior
-
Antônio José C. Filho
-
Lourivaldo S. Santos
-
Luís Cláudio N. Silva
-
Edson Rodrigues-Filho
GRAPHICAL ABSTRACT
ABSTRACT
Extracts of the endophytic fungus Glomerella cingulata grown in polish rice, were fractionated by chromatographic procedures including preparative scale HPLC. The isolated compounds were structurally elucidated through spectroscopic analysis, mainly 1H and 13C NMR and HRMS. These analyzes allowed the identification of pestalotin-1 (1) and the phthalides (3R*,8S*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide (2) and (3R*,8R*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide (3). The extracts, their fractions and isolated substances were tested against several bacteria. The lactone 2 showed some activity against lineages of E. coli and Enterococcus faecalis while its diastereoisomer 3 and pestalotin-1 were inactive.
KEYWORDS- Endophytic fungus
- Glomerella cingulata
- antimicrobial activity
