JOURNAL 2519
Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 2-March-April
Year: 2023 Issue: 2-March-April
PAGES
p.293 - 299
p.293 - 299
STATISTICS
Viewed 1770 times.
Viewed 1770 times.
AUTHORS
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Xiling Fan
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Yangang Cao
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Mengnan Zeng
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Ru Wang
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Yanling Liu
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Chen Xu
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Xinyi Ma
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Yingjie Ren
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Chen He
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Xiangda Li
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Xiaoke Zheng
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Weisheng Feng
GRAPHICAL ABSTRACT
ABSTRACT
A new lignan eplignan A (1), along with six konwn lignans (2–7) was isolated from the herbaceous stems of Ephedra intermedia Schrenket C. A. Meyer. Their structures were elucidated based on the spectroscopic evidence, mainly including NMR and HRESIMS data. The absolute configuration of 1 was determined by comparing calculated and experimental electronic circular dichroic (ECD) spectra. Moreover, all compounds (1–7) were evaluated for their protective effects against the BEAS-2B cells injury induced by TGF-β1 in vitro, and the results showed that compounds 1, 2, 4, and 6 exhibited significantly protective activities at the concentration of 10 μM.
KEYWORDS- Ephedra
- Ephedrae intermedia
- lignans
- lung protective activity
