JOURNAL 2520
Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 2-March-April
Year: 2023 Issue: 2-March-April
PAGES
p.318 - 328
p.318 - 328
STATISTICS
Viewed 1765 times.
Viewed 1765 times.
AUTHORS
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Yuze Li
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Zilong Zhang
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Wenli Huang
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Huawei Zhang
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Yi Jiang
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Jianli Liu
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Xiaomei Song
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Dongdong Zhang
GRAPHICAL ABSTRACT
ABSTRACT
Two new spirostanol glycosides, thibetanosides J and K (1 and 2), along with three known ones (3-5) were isolated from the roots and rhizomes of Helleborus thibetanus. Their structures were elucidated by extensive use of spectroscopic techniques and chemical evidence. In this study, compounds 1-5 were evaluated for their cytotoxic activity against HCT116, A549 and HepG2 tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity against A549 cells (IC50 7.69 ± 1.13 μM) and HepG 2 cells (IC50 8.32 ± 2.63 μM). Compound 2 exhibited moderate cytotoxicity against HCT116 cells (IC50 20.67 ± 1.06 μM).
KEYWORDS- Helleborus thibetanus
- spirostanol glycosides
- cytotoxic activity
