JOURNAL 2520


Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 2-March-April
PAGES
p.318 - 328
STATISTICS
Viewed 1445 times.
AUTHORS
  • Yuze Li
  • Zilong Zhang
  • Wenli Huang
  • Huawei Zhang
  • Yi Jiang
  • Jianli Liu
  • Xiaomei Song
  • Dongdong Zhang
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


 Two new spirostanol glycosides, thibetanosides J and K (1 and 2), along with three known ones (3-5) were isolated from the roots and rhizomes of Helleborus thibetanus. Their structures were elucidated by extensive use of spectroscopic techniques and chemical evidence. In this study, compounds 1-5 were evaluated for their cytotoxic activity against HCT116, A549 and HepG2 tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity against A549 cells (IC50 7.69 ± 1.13 μM) and HepG 2 cells (IC50 8.32 ± 2.63 μM). Compound 2 exhibited moderate cytotoxicity against HCT116 cells (IC50 20.67 ± 1.06 μM).

KEYWORDS
  • Helleborus thibetanus
  • spirostanol glycosides
  • cytotoxic activity

SUPPORTING INFORMATION


Supporting Information
Download File A11-361-RNP-2207-2520-SI.pdf (3.08 MB)