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Diterpenoids from the Seeds of Euphorbia Lathyris and their Cytotoxic Acitivity

Original Article

JOURNAL 2459

Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 3 May-June
PAGES
p.476 - 484
DOI ADDRESS
http://doi.org/10.25135/rnp.365.2205.2459
STATISTICS
Viewed 2385 times.
AUTHORS
  • Na Liu
  • Yajie Sun
  • Yulin Sun
  • Yilin Sun
  • Tingting Luo
  • Fengying Yang
  • Peng Wang
  • Di Ge
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

 A new lathyrane-type diterpenoid, named euphorbia factor L35 (1), along with twenty-two known analogues (2-23) were isolated from the seeds of Euphorbia lathyris. Their structures were elucidated by using 1D- and 2D-NMR spectra and HRESIMS analysis. The cytotoxic effects of the isolated compounds against BT-549 and MDA-MB-231 cancer cells lines were evaluated by the SRB assay. Compounds 3, 10, 14, and 22 were found to exhibit considerable cytotoxic activities against BT-549 cells, with IC50 values ranging from 4.7 to 10.1 μM. Compounds 1, 2, 14 and 22 were able to inhibit the MDA-MB-231 cells growth with IC50 values of 5.7 to 21.3 μM, while other compounds showed no obvious inhibitory effects.

 KEYWORDS
  • Euphorbia lathyris;
  • lathyrane-type diterpenes;
  • cytotoxic activity.

SUPPORTING INFORMATION

Supporting Information
Download File A5-365-RNP-2205-2459-SI.pdf (2.13 MB)