JOURNAL 2560
Records of Natural Products
Year: 2023 Issue: 3 May-June
p.456 - 452
Viewed 2632 times.
-
Qing Zhu
-
Can Yue Ouyang
-
Yang Liu
-
Zhangjun Xu
-
Ying Zhang
-
Ronghua Liu
-
Lanying Chen
GRAPHICAL ABSTRACT
ABSTRACT
A new chalcone compound, methyl 5-cinnamoyl-2-hydroxy-4-methoxybenzoate (1), and a new cinnamylphenol compound, methyl 3-cinnamyl-5-hydroxy-4-methoxybenzoate (2) together with four known compounds (3-6) were obtained from the CH2Cl2 soluble fraction of Dalbergia melanoxylon. Their structures were elucidated by comprehensive spectral measurements, single crystal X-ray diffraction and literature data. According to the determination results of compound 1 and 2 on RAW 264.7 cell viability, the IC50 values of compounds 1-2 were 4.11 and 113.99 μg/mL, respectively. Compared with LPS model group, compound 1 and 2 could significantly reduce the release of NO in the concentration rages of 0.375~3.0 μg/mL and 10 μg/mL (P<0.01), and significantly inhibit the secretion of LDH with 1.5~3 μg/mL and 5~10 μg/mL.
KEYWORDS- Dalbergia melanoxylon
- chalcone
- cinnamylphenol
- anti-inflammatory activity
