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Eupalinolide N, a Previously Undescribed Sesquiterpene Lactone with Anti-inflammatory Activity from Eupatorium lindleyanum

Original Article

JOURNAL 2499

Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 3 May-June
PAGES
p.529 - 535
DOI ADDRESS
http://doi.org/10.25135/rnp.368.2206.2499
STATISTICS
Viewed 2459 times.
AUTHORS
  • Jie Yan
  • Wenxiu Guo
  • Xueyan Huo
  • Yunjie Hu
  • Lanyu Zhou
  • Xiaofang Xie
  • Jin Pei
  • Yun Deng
  • Bin Xiao
  • Ding Liu
  • Dale Guo
  • Cheng Peng
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A previously undescribed sesquiterpene lactone, named eupalinolide N (1), was isolated from traditional Chinese medicine “Ye-Ma-Zhui” (Eupatorium lindleyanum) by ethanol reflux extraction, reduced pressure concentration, macroporous resin column chromatography, and C18 reversed-phase chromatography. Its structure was elucidated by a comprehensive interpretation of spectroscopy evidence as well as ECD calculations. 1 showed anti-inflammatory activity by inhibiting the gene expressions of pro-inflammatory factors including IL-1β, TNFα COX-2, and iNOS at the concentration of 7.5 μM, as well as attenuating the excretion of NO, IL-6, and TNF-α in Raw 264.7 macrophages at the concentration of 15 μM.

 KEYWORDS
  • Eupatorium lindleyanum
  • sesquiterpene lactone
  • spectroscopic analyses
  • anti-inflammatory activity

SUPPORTING INFORMATION

Supporting Information
Download File A11-368-RNP-2206-2499-SI.pdf (1.08 MB)