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A Previously Undescribed Cleistanthane-Type Diterpenoid from Peniophora incarnate

Original Article

JOURNAL 2619

Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 3 May-June
PAGES
p.522 - 528
DOI ADDRESS
http://doi.org/10.25135/rnp.374.2210.2619
STATISTICS
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AUTHORS
  • Meimei Li
  • Wenxiu Guo
  • Yu Jiang
  • Cong-cong Li
  • Xue-yan Huo
  • Yunjie Hu
  • Dale Guo
  • Li-jun Huang
  • Yun Deng
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A newly discovered cleistanthane-type diterpenoid named incarnatin A (1) was isolated from Peniophora incarnate, an endophytic fungus obtained from the roots of Ligusticum chuanxiong. Its absolute configuration was unambiguously elucidated by spectroscopic means including HRMS and NMR combined with ECD calculations. Transcriptome sequencing indicated that 1 could inhibit angiogenesis.

 KEYWORDS
  • Peniophora incarnate
  • Cleistanthane-Type diterpenoid
  • Incarnatin A
  • Structural elucidation
  • Transcriptome sequencing
  • Angiogenesis

SUPPORTING INFORMATION

Supporting Information
Download File A10-374-RNP-2210-2619-SI.pdf (1.36 MB)