A New Sesquiterpene and Two Nitro-containing Phenylpropionic Acid Derivatives from the Fungus Aspergillus terreus LPFH-1

Original Article

JOURNAL 2623

Records of Natural Products

VOLUME & ISSUE

Year: 2023 Issue: 3 May-June

PAGES

p.516 - 521

DOI ADDRESS

http://doi.org/10.25135/rnp.375.2211.2623

STATISTICS

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AUTHORS

Jingmin Wu
Linlin Qiu
Yanli Zhou
Shen Yao
Dubu Zhu

GRAPHICAL ABSTRACT

ABSTRACT

Chemical study of the fungal strain Aspergillus terreus LPFH-1 led to the isolation of 8 compounds (1-8), including a new acyclic sesquiterpenoid (1) and two new natural products (2 and 3). Their structures were determined by extensive analyses of the spectroscopic data including 1D (1H and 13C NMR) and 2D NMR (1H-1H COSY, HSQC, HMBC, NOESY) data. Compounds 2 and 3 were nitro-containing phenylpropionic acid derivatives, whose absolute configuration was determined by comparing their specific rotations with those of synthetic products. The known compounds were identified as 4-hydroxy-3-(3-methylbut-2-enyl)benzaldehyde (4), ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (5), terretonin D (6), asperterpene K (7), and asterrelenin (8).

KEYWORDS

Aspergillus terreus
marine-derived fungus
new sesquiterpenes
phenylpropionic acid

SUPPORTING INFORMATION

Supporting Information

Download File A9-375-RNP-2211-2623-SI.pdf (1.53 MB)