JOURNAL 2628


Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 3 May-June
PAGES
p.501 - 508
STATISTICS
Viewed 961 times.
AUTHORS
  • Hüseyin Akşit
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A phytochemical study on the Potamogeton pusillus L. led to the isolation and identification of a novel biflavonoid, pusillin A (1) with known seven compounds, including rosmarinic acid (2), luteolin-7-O-sulfate (3), eriodictyol-7-sulfate (4), chrysoeriol-7-sulfate (5), eriodictyol (5), luteolin (7) and chrysoeriol (8). Their structures were elucidated based on spectrometric analysis, including LC-MS/MS and NMR. All compounds were screened for in vitro antidiabetic activity using the spectrophotometric method. Sulfated flavones (1, 3, 4, and 5) exhibited prominent α-glucosidase inhibitory activity, and compounds 2, 6, 7, and 8 showed moderate inhibitory activities. All isolates were reported for the first time from the plant material.

KEYWORDS
  • Potamogeton pusillus L
  • biflavonoid
  • α-glucosidase
  • antidiabetic properties
  • sulfated flavones

SUPPORTING INFORMATION


Supporting Information
Download File A7-385-RNP-2211-2628-SI.pdf (1.96 MB)