A New Phenolic Bisabolane Sesquiterpenoid from the Fungus Aspergillus sp. Hvtc-2021zx1

The strain Aspergillus sp. Hvtc-2021zx1 was isolated and cultivated in solid-state fermentation using rice medium. The medium was extracted with ethyl acetate (EtOAc) to give an extract, which was separated by various chromatographic techniques to give five compounds including the new bisabolane 1. The structures were determined by 1H NMR, 13C NMR, 2DNMR and ESIMS data. It should be noted that an O-methyl group at C-7 as in compound 1 was rarely found in the phenolic bisabolane skeleton. The four known compounds 2-5 were identified to be 11,12-dihydroxysydonicacid (2), sydowic acid (3), cyclo(D-phenylalanyl-L-leucyl) (4), and neoechinulin A (5), respectively. The NMR data of 5 was reported for the first time in DMSO-d6. Compound 5 was active against S. aureus with an MIC value of 64 ug/mL