JOURNAL 2935


Records of Natural Products
VOLUME & ISSUE
Year: 2024 Issue: 1 January-February
PAGES
p.165 - 170
STATISTICS
Viewed 477 times.
AUTHORS
  • Mengjia Guo
  • Bo Zhou
  • Xinman Zhao
  • Manqin Fu
  • Ling Tao
  • Xiangchun Shen
  • Nenling Zhang
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Nineteen compounds were purified from leaves of Ficus carica Linn. using various separation techniques such as recrystallization, column chromatography filled with silica gel, Sephadex LH-20, and MCI, and semi-preparative HPLC. By analysis of NMR, MS, and data comparison with those reported from literatures, their structures were identified as umbelliferone (1), psoralen (2), furopinnarin (3), 6,7-furano-hydrocoumaric acid (4), (E)-3-[5-(6-hydroxy) benzofuranyl] propenoic acid (5), (E)-3-(6-hydroxy-4-methoxy-5-benzofuranyl) propenoic acid (6), nodakenetin (7), oxypeucedanin hydrate (8), dihydrofurocoumarin (9), (E)-4-hydroxy-3,3,5-trimethy1-4-(3-oxobu-1-en-1-yl)-cyclohexan-1-one (10), dehydrovomifoliol (11), 4,5-dihydroblumenol A (12), blumenol A (13), 5-hydroxy-4,7-dimethoxyisoflavone (14), cajanin (15), loliolide (16), indole-3-carboxaldehyde (17), 1H-indole-3-carboxylic acid (18), vitamin E quinone (19). Their α-glucosidase inhibitory activities were evaluated by IC50 values. Compounds 15 and 19 showed obvious α-glucosidase inhibitory activity with IC50 of 71.1±1.56 µM and 49.3 µM±1.21, respectively, and by the kinetics of enzymatic reaction, the inhibition type by which compound 15 acting against α-glucosidase was inferred as anticompetitive. Moreover, preliminary structure-activity relationship was recapticulated from the tested compounds.

KEYWORDS
  • Ficus carica Linn.
  • coumarin
  • α-glucosidase inhibitor
  • enzyme kinetics

SUPPORTING INFORMATION


Supporting Information
Download File A11-430-RNP-2310-2935-SI.pdf (2.49 MB)