JOURNAL 3022
Records of Natural Products
Year: 2024 Issue: 2 March-April
p.273 - 280
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Jing Xia
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Jianhui Liu
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Yuanqian Wang
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Shumei Shen
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Xiaoxian Song
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Guangtao Zhang
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Minghe Luo
GRAPHICAL ABSTRACT
ABSTRACT
A new butoxy substituted indolediketopiperazine (1), together with five known indolediketopiperazines (2−6), which are derivatives of brevianamides, were isolated from the marine derived fungus Aspergillus sp. 66may. Careful analysis and comparison of the HRESIMS, as well as 1D and 2D NMR datasets, identified the structures of the isolated compounds. The subsequent antibacterial and anti-inflammatory activities showed that compound 4 possessed antimicrobial bioactivities against Bacillus subtilis ATCC 39620 with minimum inhibitory concentration (MIC) value of 64 μg/mL. Compounds 1, 2, 4 exhibited potential inhibitory activities against NO production with IC50 value of 28.2, 21.3, 23.6 μM, respectively. It seems that butoxy substitution at C-9 in brevianamides have little effects on their antimicrobial and anti-inflammatory bioactivities.
KEYWORDS- Diketopiperazines
- brevianamide
- antibacterial activity
- anti-inflammatory
