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Phytosteroids from Roots of Psammosilene tunicoides W.C.Wu et C.Y.Wu

Short Report

JOURNAL 2991

Records of Natural Products
VOLUME & ISSUE
Year: 2024 Issue: 2 March-April
PAGES
p.290 - 295
DOI ADDRESS
http://doi.org/10.25135/rnp.444.2312.2991
STATISTICS
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AUTHORS
  • Yanhong Li
  • Ziliang Wang
  • Hongrui Li
  • Yuxiao Li
  • Kexin Nie
  • Xiuxia Yang
  • Xishan Bai
  • Xiangzhong Huang
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

To explore structurally and pharmacologically interesting secondary metabolites from Psammosilene tunicoides, a crude extract of this plant was investigated, leading to the isolation of a new phytoecdysteroid, furoecdysterone (1) and four known phytosteroid compounds, ecdysterone (2), 22-deoxyecdysterone (3), β-sitosteryl d-glucoside (4), and b-sitosterol (5). Their structures were identified based on a detailed analysis of NMR spectra and MS data. Those compounds, except for 2, showed moderate NO inhibition activities on lipopolysaccharide (LPS)-induced release in RAW 264.7 cells.

 KEYWORDS
  • Psammosilene tunicoides
  • phytoecdysteroid
  • nitric oxide inhibition activity
  • RAW 264.7 cells

SUPPORTING INFORMATION

Supporting Information
Download File A11-444-RNP-2312-2991-SI.pdf (3.73 MB)