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A Novel Limonoid from the Seeds of Chisocheton macrophyllus

Short Report

JOURNAL 2960

Records of Natural Products
VOLUME & ISSUE
Year: 2024 Issue: 3 May-June
PAGES
p.347 - 351
DOI ADDRESS
http://doi.org/10.25135/rnp.451.2311.2960
STATISTICS
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AUTHORS
  • Nurlelasari
  • Muhammad Huda
  • Wahyu Safriansyah
  • Unang Supratman
  • Yudha Budiman
  • Desi Harneti P. Huspa
  • Rani Maharani
  • Tri Mayanti
  • Kindi Farabi
  • Sofa Fajriah
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

This study aimed to isolate a novel limonoid compound, (6R,7S, 8R, 9R, 10R, 11R, 13S, 17R)-17-(furan-3-yl) -4, 4, 8, 10, 13-pentamethyl-3-oxo-4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17-dodecahydro-3H-cyclopenta[a]phenanthrene-6,7,11-triyltriacetate (11α-acetoxydysobinin) (1), and 3 pre-existing limonoids, namely dysobinin (2), dysobinol (3), and 7-deacetylepoxyazadiradione (4) from the seeds of Chisocheton macrophyllus (Meliaceae). In addition, the structure of the isolated compounds was determined using various spectroscopic techniques, including UV, IR, HRTOFMS, 1D, and 2D NMR. The cytotoxic effects of each compound were then evaluated against breast cancer cells of the Michigan Cancer Foundation-7 (MCF-7), but no significant activity was observed.

 KEYWORDS
  • Chisocheton macrophyllus
  • Meliaceae
  • limonoid
  • cytotoxic activity
  • MCF-7

SUPPORTING INFORMATION

NMR spectra for structural determination
Download File SM_Nurlelasari_RNP_Short report_2023.doc (1.74 MB)