Peniciloxatone A, a New Polyoxygenated Ergostane Steroid Isolated from the Marine Alga-Sourced Fungus Penicillium oxalicum 2021CDF-3

Short Report

JOURNAL 3339

Records of Natural Products

VOLUME & ISSUE

Year: 2024 Issue: 6 November-December

PAGES

p.699 - 704

DOI ADDRESS

http://doi.org/10.25135/rnp.486.2410.3339

STATISTICS

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AUTHORS

Fangfang Lu
Wei Song
He Li
Longhe Cao

GRAPHICAL ABSTRACT

ABSTRACT

Chemical investigations on the culture of Penicillium oxalicum 2021CDF-3, a marine red alga-sourced endophytic fungus, revealed a new steroid, namely peniciloxatone A (1). With the aid of high-resolution electrospray ionization mass spectrometry (HRESIMS) and nuclear magnetic resonance (NMR) analyses, the structure of peniciloxatone A (1) was determined to be a polyoxygenated ergostane steroid. Cytotoxic activities of 1 were tested against A549, FADU, and HepG2 cells, and 1 was active against the FADU and HepG2 cells, with IC50 values of 9.5 ± 0.1 and 18.1 ± 0.3 μM, respectively.

KEYWORDS

Penicillium oxalicum
secondary metabolites
natural product
steroid
cytotoxicity

SUPPORTING INFORMATION

Supporting Information

Download File A11-486-RNP-2410-3339-SI.pdf (1.75 MB)