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Chemical Constituents of Siegesbeckia orientalis and Their Anti-Proliferative Activity

Original Article

JOURNAL 3381

Records of Natural Products
VOLUME & ISSUE
Year: 2025 Issue: 1 January-February
PAGES
p.75 - 83
DOI ADDRESS
http://doi.org/10.25135/rnp.494.2412.3381
STATISTICS
Viewed 265 times.
AUTHORS
  • Rongxian Li
  • Di Ge
  • Wenying Yin
  • Yongqi Zhang
  • Mengjia Liu
  • Han Xue
  • Xianshou Zhao
  • Na Liu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new germacrane-type sesquiterpenoid compound (1) and four known compounds (2-5) were isolated from Siegesbeckia orientalis. Chemical structures of these compounds were elucidated using 1D and 2D NMR spectroscopic data, HR-ESIMS, electronic circular dichroism (ECD) and compared with the literature. Their anti-proliferative effects were evaluated on human triple-negative breast cancer (TNBC) cell line MDA-MB-231. The results demonstrated that compound 2 significantly inhibits the proliferation of MDA-MB-231 cells by inducing apoptosis.

 KEYWORDS
  • Siegesbeckia orientalis
  • germacrane-type sesquiterpenoids
  • anti-proliferative activity

SUPPORTING INFORMATION

Supporting Information
Download File 494-RNP-2412-3381-SI.pdf (2.36 MB)