JOURNAL 3404
Records of Natural Products
Year: 2025 Issue: 1 January-February
p.84 - 94
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GRAPHICAL ABSTRACT
ABSTRACT
In this study, the phytochemical constituents of Davallia bullata rhizomes essential oil (DBEO) and its biological activities were investigated. According to the GC-FID and GC-MS analysis, the major compounds of DBEO were found to be β-barbatene (17.2%), n-hexadecanoic acid (6.6%), oleic acid (5.7%), nonanal (5.5%), and 1-octen-3-ol (4.9%). For biological activities, DBEO was tested against gram-positive bacteria, B. subtilis and S. aureus, and gram-negative bacteria, E. coli and P. aeruginosa, in order to determine its potential antibacterial activity. The results revealed minimal inhibitory concentration values in the range of 0.16–0.64 mg/mL, while minimum bactericidal concentration values ranged from 0.16 to 1.28 mg/mL. Interestingly, DBEO possessed remarkable synergistic effects when combined with chloramphenicol and streptomycin, with the fractional inhibitory concentration indexes (FICI) varying from 0.13 to 0.50, as determined by the Checkerboard method. Furthermore, DBEO exhibited a moderate level of cytotoxicity against MCF-7, HepG2, HCT-116, and A-549 cells with IC50 values varying from 58.38 ± 0.19 to 94.37 ± 5.09 μg/mL and weak cytotoxicity against non-cancerous HL-7702 cells (177.05 ± 1.34 μg/mL), and the antioxidant capacity of DBEO was evaluated and reported herein.
KEYWORDS- Davallia bullata
- essential oil
- antibacterial
- synergistic
- cytotoxic
- antioxidant
