JOURNAL 3694
Records of Natural Products
VOLUME & ISSUE
Year: 2026 Issue: 2
Year: 2026 Issue: 2
PAGES
p.4 - 4
p.4 - 4
STATISTICS
Viewed 13 times.
Viewed 13 times.
AUTHORS
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Zi-Kang Zhao
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Lin-Fang Tang
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Han-Jun Guo
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Yuan Chen
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Meng-Meng Hu
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Yu-Bing Hong
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Rong Zhao
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Mingming Cao
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Jia Chen
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Yan-Yun Che
GRAPHICAL ABSTRACT
ABSTRACT
In this study, a previously undescribed glutarylimide compound was isolated from Streptomyces sp. JCM 4793. Its structure was evaluated through examinations of the NMR, HREIMS data and ECD calculation. Compound 1 was measured for its cytotoxicities against A549, K562, HepG2, SW480 and MDA-MB-231 cells. Compound 1 exhibited significant inhibitory activity against both K562 and A549 tumor cell lines, with IC50 values of 4.840 ± 0.329 μmol/L and 6.036 ± 0.157 μmol/L, respectively.
KEYWORDS- Streptomyces
- glutarimide
- configuration
- cytotoxicities
