JOURNAL 3379
Records of Natural Products
VOLUME & ISSUE
Available Online: March 06,2025
Available Online: March 06,2025
PAGES
p.1 - 6
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.500.2412.3379 (DOI number will be activated after the manuscript has been available in an issue.)
http://doi.org/10.25135/rnp.500.2412.3379 (DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 214 times.
Viewed 214 times.
GRAPHICAL ABSTRACT
ABSTRACT
One new diterpene with a fused 6-5-6-6 ring system, trichodermanin I (1), along with three known ones, wickerols A and B and trichodermanin F (2-4), were acquired from the extract of Trichoderma atroviride YD-13 isolated from soil. Their chemical structures were determined by interpretation of 1D/2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. Compound 1 was evaluated for inhibiting the growth of four human pathogenic bacteria (Clostridium botulinum, Escherichia coli, Salmonella, and Staphylococcus aureus) and exhibited potential antibacterial activity against C. botulinum, E. coli, and S. aureus with MIC values of 8.0 μg/mL, 32 μg/mL, and 16 μg/mL, respectively.
KEYWORDS- Trichoderma atroviride
- diterpene
- secondary metabolites
- antibacterial activity
