A New Benzofuran from the Roots of Eupatorium chinense L. and Its α-glucosidase and PTP1B Inhibitory Activities

Short Report

JOURNAL 3280

Records of Natural Products
VOLUME & ISSUE
Available Online: November 02,2024
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.483.2408.3280
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Qiangsu Qin
  • Huishu Yang
  • Yifa Qin
  • Yifan Bai
  • Renqin Tang
  • Ting Yan
  • Zhaoxia Liu
  • Chengxiong Liu
  • Xiaoqin Yu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new benzofuran, named eupbenzofuran A (1), along with four known compounds, 10,11-dihydroxy-10,11-dihydroeuparin (2), 5-[1'-hydroxyethyl]-2-1'-hydroxyisoprolyl]-benzofuran (3), 3α,6-dihydroxytremetone (4), odoratin (5) were isolated from the roots of Eupatorium chinense L. The structure of compounds were identified by NMR, MS, CD and other spectroscopic methods and comparisons with relevant literature data. Compound 1 had favorable dual inhibitory activities against α-glucosidase and protein tyrosine phosphatase 1B (PTP1B). However, compounds 2-5 had no significant inhibitory activities effects on α-glucosidase and PTP1B (IC50＞50 μg/mL). Molecular docking technique was used to calculate the interaction of compound 1 with α-glucosidase and PTP1B, respectively, and the calculated results showed that compound 1 had both strong binding to α-glucosidase and PTP1B.

 KEYWORDS
  • Eupatorium chinense L.
  • chemical constituents
  • antidiabetic activity
  • α-glucosidase
  • protein tyrosine phosphatase 1B

SUPPORTING INFORMATION

Supporting Information
Download File 483-RNP-2408-3280-SI.pdf (1.73 MB)