Peniciloxatone A, a New Polyoxygenated Ergostane Steroid Isolated from the Marine Alga-Sourced Fungus Penicillium oxalicum 2021CDF-3

Short Report

JOURNAL 3339

Records of Natural Products
VOLUME & ISSUE
Available Online: November 10,2024
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.486.2410.3339
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 313 times.
AUTHORS
  • Fangfang Lu
  • Wei Song
  • He Li
  • Longhe Cao
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Chemical investigations on the culture of Penicillium oxalicum 2021CDF-3, a marine red alga-sourced endophytic fungus, revealed a new steroid, namely peniciloxatone A (1). With the aid of high-resolution electrospray ionization mass spectrometry (HRESIMS) and nuclear magnetic resonance (NMR) analyses, the structure of peniciloxatone A (1) was determined to be a polyoxygenated ergostane steroid. Cytotoxic activities of 1 were tested against A549, FADU, and HepG2 cells, and 1 was active against the FADU and HepG2 cells, with IC50 values of 9.5 ± 0.1 and 18.1 ± 0.3 μM, respectively.

 KEYWORDS
  • Penicillium oxalicum
  • secondary metabolites
  • natural product
  • steroid
  • cytotoxicity

SUPPORTING INFORMATION

Supporting Information
Download File 486-RNP-2410-3339-SI.pdf (1.44 MB)