An efficient and eco-friendly synthesis of 1, 4-dihydropyridines via Hantzsch reaction in Glycine-HCl buffer as solvent and bio-catalyst
Year: 2019 Issue: 2 April-June
p.109 - 114
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- 1 - Islamic Azad University Khoy Branch, Khoy, West Azarbaijan. Iran
- 2 - islamic azad university, khoy branch
- 3 - islamic azad university khoy branch
A green and efficient procedure was established to synthesize 1,4-dihydropyridines via one-pot Hantzsch reactions in buffering conditions without the use of organic solvent. In this method, a buffer solution was used as solvent and catalyst reaction; therefore, using this method has several benefits including high yields, an environmentally friendly procedure, short reaction times, and a simple work-up procedure. All the compounds were characterized by TLC, FT-IR, 1H NMR and elemental studies.
- Hantzsch reaction
- glycine-HCl buffer
- green procedure