Oxidation of hesperidin into diosmin using ionic liquids

Original Article

JOURNAL 1242

Organic Communications

VOLUME & ISSUE

Year: 2019 Issue: 2 April-June

PAGES

p.101 - 108

DOI ADDRESS

http://doi.org/10.25135/acg.oc.57.19.04.1242

STATISTICS

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AUTHORS

V-thanh Nguyen
T.kim-chi Huynh
Thanh-danh Nguyen
Kim-dung Hoang

GRAPHICAL ABSTRACT

ABSTRACT

In this study, ionic liquids (ILs) were first used as solvents for conversion of hesperidin into diosmin. The diosmin was successfully synthesized by using iodine oxidation in ionic liquids including [BMIM]Br, [BMIM]BF4, [BMIM]OTf, [BPY]Br, [BPY]BF4 and [BPY]OTf. The results showed the reaction achieved in good yields (57- 76%). Among them, [BPY]Br and [BPY]BF4 exhibited as excellent solvents for the oxidation of hesperidin. In particular, water content in recovered ionic liquids (ILs), which affected strongly recyclable performance in the oxidation of hesperidin, has been investigated. It found that water content in [BPY]Br from 1 % to 5% (v/v) induced a significant increase of the synthetic yield.

KEYWORDS

diosmin
oxidation
hesperidin
synthesis
ionic liquid