JOURNAL


Organic Communications
VOLUME & ISSUE
Year: 2019 Issue: 2 April-June
PAGES
p.101 - 108
STATISTICS
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AUTHORS
  • V-thanh Nguyen
  • T.kim-chi Huynh
  • Thanh-danh Nguyen
  • Kim-dung Hoang
  • 1 - Vietnam Academy of Science and Technology, Institute of Chemical Technology
  • 2 - Vietnam Academy of Science and Technology, Institute of Chemical Technology
  • 3 - Vietnam Academy of Science and Technology, Institute of Chemical Technology
  • 4 - Vietnam Academy of Science and Technology, Institute of Chemical Technology
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ABSTRACT


In this study, ionic liquids (ILs) were first used as solvents for conversion of hesperidin into diosmin. The diosmin was successfully synthesized by using iodine oxidation in ionic liquids including [BMIM]Br, [BMIM]BF4, [BMIM]OTf, [BPY]Br, [BPY]BF4 and [BPY]OTf.  The results showed the reaction achieved in good yields (57- 76%). Among them, [BPY]Br and [BPY]BF4 exhibited as excellent solvents for the oxidation of hesperidin. In particular, water content in recovered ionic liquids (ILs), which affected strongly recyclable performance in the oxidation of hesperidin, has been investigated. It found that water content in [BPY]Br  from 1 % to 5% (v/v) induced a significant increase of the synthetic yield.

KEYWORDS
  • diosmin
  • oxidation
  • hesperidin
  • synthesis
  • ionic liquid