Organic Communications

Year: 2014 Volume: 7 Issue:2 April-June

Original Article

1) A facile one-pot synthesis of 3-(1-Benzyl-2-phenyl-1H-imidazol-4-yl)-4-hydroxy-6-methyl-2H-pyran-2-one derivatives via multi-component approach

Org. Commun. (2014) 7:2 ; 53 - 59
by Thirupaiah Bade and Rajeswar Rao Vedula

A one pot, four component synthesis of 1, 2, 4-trisubstituted imidazoles is described by reacting a mixture of bromo dehydroacetic acid, aromatic aldehyde, benzyl amine, and ammonium acetate in dry alcohol. All the synthesized compounds were characterized by their analytical and spectral data.

Keywords
bromo dehydroacetic acid aromatic aldehyde benzyl amine ammonium acetate imidazole one-pot
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© 2014 ACG Publications. All rights reserved.
Original Article

2) Microwave induced synthesis of bis-Schiff bases from propane-1, 3-diamine as promising antimicrobial analogs

Org. Commun. (2014) 7:2 ; 60 - 67
by Avinash Shinde, Sainath Zangade, Shivaji Chavan and Yeshwant Vibhute

1,3-Diamine 1 on condensation with different halogeno substituted benzaldehydes 2a-p under microwave irradiation affords novel series of bis-schiff bases 3a-p. Structures of the newly synthesized bis-Schiff bases established on the basis of spectroscopic data. Further, all compounds screened for antimicrobial activity against Staphylococus aureusEscherchia coli, Aspergillus niger and Aspergillus flavus. Most of the titles compounds show potent activity.

Keywords
1 3-Diamine bis-schiff bases microwave irradiation microbial activity
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© 2014 ACG Publications. All rights reserved.
Original Article

3) Eco-friendly synthesis of novel indeno-pyrazole derivatives and their in-vitro antimicrobial screening

Org. Commun. (2014) 7:2 ; 68 - 76
by Ashok P. Acharya, Rahul D. Kamble, Shrikant V. Hese, Shuddhodan N. Kadam, Rajesh N. Gacche and Bhaskar S. Dawane

In the present communication a series of novel indeno-pyrazole derivatives were synthesized by the reaction of α, β-unsaturated ketones with phenyl hydrazine in polyethylene glycol-400 (PEG-400) and few drop of acetic acid. The newly synthesized compounds were characterized and confirmed by IR, 1H-NMR, 13C-NMR and mass spectral data. The results obtained indicate the significance of indeno-pyrazole derivatives as potent scaffold for designing novel and broad spectrum antimicrobials.

Keywords
Indeno -Pyrazole derivatives bleaching earth clay (pH12.5) Polyethylene glycol-400(PEG-400) Antimicrobial activity
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© 2014 ACG Publications. All rights reserved.
Original Article

4) Regioselective synthesis of new variety of 1,4-benzothiazines

Org. Commun. (2014) 7:2 ; 77 - 84
by Mohamed Saadouni, Tourya Ghailane, Said Boukhris, Amina Hassikou, Nouzha Habbadi, Rachida Ghailane, Mohamed Harcharras, Abdelaziz Souizi and Hassen Amri

A facile and regioselective synthesis of 1, 4-benzothiazines was achieved with a variety of a -cyano a -alkoxy carbonyl epoxides and 2-aminothiophenol in the presence or no of HCl in the reaction medium. The structures of the newly synthesized compounds were confirmed by spectral studies.

Keywords
a -cyano a -alkoxy carbonyl 2-aminothiophenol regioselective 1 4-benzothiazines
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© 2014 ACG Publications. All rights reserved.