JOURNAL 188


Organic Communications
VOLUME & ISSUE
Year: 2011 Issue: 4 October-December
PAGES
p.105 - 111
STATISTICS
Viewed 1363 times.
AUTHORS
    Somisetti Narender Rao 1 and K. Sudhakar Babu
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Development of a new improved and efficient process suitable for the large-scale production of Irbesartan has been described. The key steps are tetrazole formation from secondary amide for the preparation of the key intermediate 1-Benzyl-5-(4'-bromomethyl-biphenyl-2-yl)-1H-tetrazole (9), N-alkylation and debenzylation.

KEYWORDS
  • Irbesartan
  • antihypertensive drug
  • tetrazole formation
  • debenzylation.