An improved and efficient synthesis of Irbesartan, an antihypertensive drug
Year: 2011 Issue: 4 October-December
p.105 - 111
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Somisetti Narender Rao 1 and K. Sudhakar Babu
Development of a new improved and efficient process suitable for the large-scale production of Irbesartan has been described. The key steps are tetrazole formation from secondary amide for the preparation of the key intermediate 1-Benzyl-5-(4'-bromomethyl-biphenyl-2-yl)-1H-tetrazole (9), N-alkylation and debenzylation.KEYWORDS
- antihypertensive drug
- tetrazole formation