PREVIOUS ARTICLE
 

An improved and efficient synthesis of Irbesartan, an antihypertensive drug

Original Article

JOURNAL 188

Organic Communications
VOLUME & ISSUE
Year: 2011 Issue: 4 October-December
PAGES
p.105 - 111
STATISTICS
Viewed 2599 times.
AUTHORS
    Somisetti Narender Rao 1 and K. Sudhakar Babu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Development of a new improved and efficient process suitable for the large-scale production of Irbesartan has been described. The key steps are tetrazole formation from secondary amide for the preparation of the key intermediate 1-Benzyl-5-(4'-bromomethyl-biphenyl-2-yl)-1H-tetrazole (9), N-alkylation and debenzylation.

 KEYWORDS
  • Irbesartan
  • antihypertensive drug
  • tetrazole formation
  • debenzylation.