JOURNAL 2140


Organic Communications
VOLUME & ISSUE
Year: 2021 Issue: 3 July-September
PAGES
p.270 - 279
STATISTICS
Viewed 254 times.
AUTHORS
  • İrfan Çapan
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The carbazole skeleton is the key structural motif of many bioactive molecules including synthetic and natural products. The carbazole derivatives bearing different functional groups have important pharmacological activities and are widely used in medicine and pharmacology. Ethyl 9H-carbazol-9-yl acetate was synthesized from the reaction of the carbazole with ethyl bromoacetate. The acetate ester derivative was converted into the 2-(9H-carbazol-9-yl) acetohydrazide through treatment with hydrazine hydrate. The target compounds were synthesized by using carbazole-hydrazide compound and various aromatic acid chlorides. Acetyl benzohydrazide derivatives were prepared from the nucleophilic addition-elimination reactions of corresponding benzoyl chloride and 2-(9H-carbazol-9-yl) acetohydrazide in THF at room temperature condition. The structures of all newly synthesized compounds were characterized using different spectroscopic techniques, such as FT-IR, 1H NMR, 13C NMR, and HRMS.    The urease enzyme activities of these compounds were investigated using Jack bean urease as the model enzyme.

KEYWORDS
  • Acetyl Benzohydrazide
  • carbazole
  • urease inhibitors

SUPPORTING INFORMATION


Supporting Information
Download File A5-109-OC-2107-2140-SI.pdf (3.68 MB)