JOURNAL 2370


Organic Communications
VOLUME & ISSUE
Year: 2022 Issue: 2 April-June
PAGES
p.117 - 128
STATISTICS
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AUTHORS
  • Rahul Rayani
  • Jigar Y. Soni
  • Deepa R. Parmar
  • Rakesh V. Kusurkar
  • Anand Vala
  • Vishwanath Zunjar
  • Satyanarayan Battula
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Modified biotin derivatives are effective in killing cancer. Herein we describe the design and synthesis of conjugated biotin-pyrazole derivatives 3a-3h to evaluate as potential anticancer agents. A set of compounds has been prepared by palladium catalysed aminocarbonylation using carbon monoxide in an autoclave. They were well characterized by various spectroscopic techniques and screened for anticancer activity. A cell viability assay (MTT assay) was performed on U251, A549, and HepG2 cell lines and determined their IC50 value. Among target agents, 3a had a considerable activity against human brain cancer cell line U251 (IC50 3.5 µM). 3a could be a promising candidate for the development of new drugs to treat tumours, particularly for brain cancer.

KEYWORDS
  • Anti-proliferative
  • aminocarbonylation
  • biotin
  • cancer
  • pyrazole
  • Swissadme

SUPPORTING INFORMATION


Supporting Information
Download File A4-132-OC-2203-2370-SI.pdf (804.26 KB)