JOURNAL 2370
Organic Communications
Year: 2022 Issue: 2 April-June
p.117 - 128
Viewed 1156 times.
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Rahul Rayani
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Jigar Y. Soni
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Deepa R. Parmar
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Rakesh V. Kusurkar
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Anand Vala
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Vishwanath Zunjar
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Satyanarayan Battula
GRAPHICAL ABSTRACT
ABSTRACT
Modified biotin derivatives are effective in killing cancer. Herein we describe the design and synthesis of conjugated biotin-pyrazole derivatives 3a-3h to evaluate as potential anticancer agents. A set of compounds has been prepared by palladium catalysed aminocarbonylation using carbon monoxide in an autoclave. They were well characterized by various spectroscopic techniques and screened for anticancer activity. A cell viability assay (MTT assay) was performed on U251, A549, and HepG2 cell lines and determined their IC50 value. Among target agents, 3a had a considerable activity against human brain cancer cell line U251 (IC50 3.5 µM). 3a could be a promising candidate for the development of new drugs to treat tumours, particularly for brain cancer.
KEYWORDS- Anti-proliferative
- aminocarbonylation
- biotin
- cancer
- pyrazole
- Swissadme
