Synthesis and biological activities of substituted 1,3,4-oxadiazolines

Original Article

JOURNAL 2717

Organic Communications

VOLUME & ISSUE

Year: 2023 Issue: 1 January-March

PAGES

p.35 - 45

DOI ADDRESS

http://doi.org/10.25135/acg.oc.146.2302.2717

STATISTICS

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AUTHORS

Hany M. Dalloul
Kholoud R. Abu Yunis

GRAPHICAL ABSTRACT

ABSTRACT

A new series of N-butyryl-1,3,4-oxadiazolines were synthesized via oxidative cyclization reaction of different benzoyl hydrazones with butyric anhydride. The structures of obtained compounds were confirmed by IR, MS, 1H NMR, 13C NMR and Elemental analysis methods and are in full agreement with their molecular structure. The synthesized 1,3,4-oxadiazolines were screened for in vitro for their biological activity against a variety of bacterial strains (Euterococci, Escherichia coli, Staphylococcus aureus, Klebsiella spp, Proteus spp, and fungi (Aspergillus niger, Candida albicans), employing the nutrient agar disc diffusion method. The obtained results showed that these compounds have good inhibition against the tested pathogens.

KEYWORDS

1,3,4-Oxadiazolines
N-acylhydrazones
spiro-oxadiazole
oxidative cyclization