JOURNAL 2834
Organic Communications
VOLUME & ISSUE
Year: 2023 Issue: 3 July-September
Year: 2023 Issue: 3 July-September
PAGES
p.142 - 151
p.142 - 151
STATISTICS
Viewed 487 times.
Viewed 487 times.
AUTHORS
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Venkata Lakshmi Reddy Sana
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Mavallur Varalakshmi
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Kiran Yerragudibathal Reddy
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Swarupa Chinthala
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Venkata Ramana Katla
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Chamarthi Naga Raju
GRAPHICAL ABSTRACT
ABSTRACT
A series of new carbamates and sulfonamide derivatives of cis-tramadol 5(a-e) and 7(a-e) have been synthesized in high yields by the reaction of cis-tramadol with various chloroformates 4(a-e) and sulfonyl chlorides 6(a-e). All the newly synthesized compounds were characterized by IR, NMR (1H and 13C), mass and elemental analyses. The synthesized compounds were evaluated for their antibacterial and antifungal activities. Compounds 5a, 5b, 7a and 7c exhibited potent antibacterial and antifungal activity.
KEYWORDS- cis-Tramadol
- carbonyl chloridates
- sulfonyl chlorides
- antibacterial
- antifungal activity
