JOURNAL 3412


Organic Communications
VOLUME & ISSUE
Year: 2025 Issue: 1 January-March
PAGES
p.17 - 27
STATISTICS
Viewed 118 times.
AUTHORS
  • Qasim Ullah
  • Samreen Kausar
  • Abida Murtaza
  • Aarifa Maryam
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


In the present study, we have developed an efficient N-acetylation method of anilines under green and eco-friendly conditions, where Baker’s Yeast (BY) was used as biocatalyst. The results of this study clearly demonstrate towards the N-acetylation of only anilines to form acetanilides (3a-i) with acetic anhydride in good to excellent yield. Interestingly, acetylation of phenol/thiophenol, aliphatic amines/heterocyclic amines and amino acids failed under the same conditions. This N-acetylation reaction with substrate-selective follows simple procedure and requires simple work up. Thus, we can conclude that the present method is a simple, efficient, substrate selective and eco-friendly.

KEYWORDS
  • Anilines
  • acetylation
  • acetanilide
  • acedic anhydride
  • Baker yeast
  • bio-catalyst

SUPPORTING INFORMATION


Supporting Information
Download File 181-OC-2501-3412-SI.pdf (1.23 MB)