JOURNAL 1983


Records of Natural Products
VOLUME & ISSUE
Year: 2021 Issue: 6 November-December (Special Issue Dedicated to the Memory of Professor Ayhan Ulubelen)
PAGES
p.513 - 528
STATISTICS
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AUTHORS
  • Hatice Kızıltaş
  • Zeynebe Bingöl
  • Ahmet C. Gören
  • Saleh H. Alwasel
  • İlhami Gülçin
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


To evaluate the antioxidant activity of evaporated ethanolic extract of Ferula orientalis L. (EEFO) and lyophilized water extract of Ferula orientalis L. (WEFO) several in vitro antioxidant methods such as ABTS•+ scavenging activity, DPPH· scavenging activity, Fe3+reduction method, cupric ions (Cu2+) reduction capacity, and metal ion (Fe2+)-binding activities using ferrozine reagent were separately performed. Also, BHT, α-tocopherol and ascorbic acid were used as the standard antioxidant molecules. Moreover, some phenolic compounds that are responsible for antioxidant abilities of EEFO and WEFO were determined by LC-HRMS. EEFO and WEFO demonstrated effective antioxidant abilities when compared with the standards. EEFO demonstrated IC50 values of 1.946 µg/mL against acetylcholinesterase (AChE), 0.815 µg/mL against α-glycosidase, and 0.675 µg/mL against α-amylase.

KEYWORDS
  • Ferula orientalis
  • α-glycosidase
  • antioxidant activity
  • phenolic compound
  • acetylcholinesterase
  • α-amylase

SUPPORTING INFORMATION


Supporting Information
Download File A7-236-RNP-2102-1983-SI.pdf (904.65 KB)