Cytotoxic Sesquiterpene Coumarins from the Roots of Heptaptera cilicica

Original Article

JOURNAL 1990

Records of Natural Products

VOLUME & ISSUE

Year: 2021 Issue: 6 November-December (Special Issue Dedicated to the Memory of Professor Ayhan Ulubelen)

PAGES

p.529 - 536

DOI ADDRESS

http://doi.org/10.25135/rnp.242.21.02.1990

STATISTICS

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AUTHORS

Fatma Tosun
Erdi C. Aytar
John A. Beutler
Jennifer A. Wilson
Mahmut Miski

GRAPHICAL ABSTRACT

ABSTRACT

Preliminary 2-day cancer cell screening assays indicated that the dichloromethane extract of the roots of Heptaptera cilicica showed relatively strong cytotoxic activity. Eleven sesquiterpene coumarin ethers with potent and selective cytotoxic activities were isolated from the dichloromethane extract of the roots of H. cilicica. Furthermore, revised spectroscopic data for 14′-acetoxybadrakemone (4) and complete NMR spectroscopic assignments for colladonin (6) and colladin (7) are reported.

KEYWORDS

Heptaptera cilicica
Apiaceae
sesquiterpene coumarins
cytotoxic activity

SUPPORTING INFORMATION

Supporting Information

Download File A8-242-RNP-2102-1990-SI.pdf (1.26 MB)